adc payload — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T14348	Auristatin E		Microtubule Associated
	Auristatin E, a cytotoxic tubulin modifier, disrupts cell division by inhibiting tubulin polymerisation. This compound demonstrates potent and selective antitumor activities, serving as an MMAE analog and cytotoxin in an...		Microtubule Associated
T38889	Thailanstatin A
	Thailanstatin A is an ultra-potent inhibitor of eukaryotic RNA splicing (IC50 =650 nM). Thailanstatin A inhibits multiple cancer cell lines via non-covalent binding to the SF3b subunit of the U2 snRNA subcomplex of the s...
T14349	Auristatin F		Microtubule Associated
	Auristatin F is an effective inhibitor of microtubule and vascular damaging agent. Auristatin F can be used in antibody-drug conjugates.		Microtubule Associated
T11249L	Dxd	Exatecan derivative for ADC,OQM5SD32BQ,UNII-OQM5SD32BQ	Topoisomerase
	Dxd (OQM5SD32BQ) is a potent inhibitor of DNA topoisomerase I with an IC50 of 0.31 μM. It is used as a conjugated drug of HER2-targeting ADC.		Topoisomerase
T15141	DM4	Ravtansine	Others , Microtubule Associated
	DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.		Others , Microtubule Associated
T11120	Duocarmycin TM		DNA Alkylation , Antibiotic
	Duocarmycin TM is a DNA alkylator. Duocarmycin TM is an exceptionally potent antitumor antibiotic.		DNA Alkylation , Antibiotic
T3256	MMAF	MonoMethyl auristatin F	Others , Microtubule Associated
	MMAF (MonoMethyl auristatin F), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin.		Others , Microtubule Associated
T8003	Methotrexate disodium		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
	Methotrexate disodium is an tetrahydrofolate dehydrogenase inhibitor		Apoptosis , Dehydrogenase , DNA/RNA Synthesis , Antifolate
T0968	Paclitaxel	Taxol,NSC 125973	Apoptosis , Microtubule Associated , Autophagy
	Paclitaxel (Taxol) is a natural product and a microtubule polymer stabilizer. Paclitaxel has anti-tumor activity and causes cell death by inducing mitotic arrest, apoptosis, and cell autophagy.		Apoptosis , Microtubule Associated , Autophagy
T12081	MMAF-OMe	Monomethyl auristatin F methyl ester
	MMAF-OMe (Monomethyl auristatin F methyl ester) is an antitubulin agent which inhibits several tumor cell lines with IC50s of 0.056 nM, 0.166 nM, 0.183 nM, and 0.449 nM for MDAMB435/5T4, MDAMB361DYT2, MDAMB468, and Raji ...
T16016	Maytansinol	Ansamitocin P-0	Apoptosis , Microtubule Associated
	Maytansinol (Ansamitocin P-0) inhibits microtubule assembly and causes microtubule disassembly in vitro.		Apoptosis , Microtubule Associated
T6897	Monomethyl auristatin E	Vedotin,MMAE	Apoptosis , Microtubule Associated
	Monomethyl auristatin E (MMAE) (MMAE), an antimitotic agent, inhibits cell division by blocking the polymerization of tubulin and also has inhibition of antibody-drug conjugates (ADCs) activity.		Apoptosis , Microtubule Associated
T16557	PNU-159682		Topoisomerase
	PNU-159682 is a highly effective metabolite of the anthracycline nemorubicin. PNU-159682 has outstanding cytotoxicity. PNU-159682 is an effective ADCs cytotoxin.		Topoisomerase
T1992	Mertansine	DM1,Maytansinoid DM1	Microtubule Associated
	Mertansine (DM1) refers to the thiol-containing maytansinoid, DM1 (N2'-deacetyl-N2'-(3-mercapto-1-oxopropyl)maytansine) attached to a monoclonal antibody through reaction of the thiol group with the SPP (N-succinimidyl 4...		Microtubule Associated
T21408	DM1-SMe	DM1-SSMe	Microtubule Associated
	DM1-SMe (DM1-SSMe) is a potent inhibitor of maytansinoid microtubular. DM1-SMe is about 3 to 10-fold more potent than the parent drug Maytansine, with IC50s of 0.003 to 0.01 nM for DM1-SMe in a panel of human tumor cell ...		Microtubule Associated
T14858	Calicheamicin	Calicheamicin γ1	Others
	Calicheamicin (Calicheamicin γ1) is an antitumor antibiotic and is a DNA synthesis inhibitor. It also is a cytotoxic agent that causes double-strand DNA breaks.		Others
T1123	Camptothecin	NSC-100880,Campathecin,(S)-(+)-Camptothecin,CPT	Apoptosis , Influenza Virus , Topoisomerase , Antibiotic , Antifungal
	Camptothecin (CPT) belongs to the alkaloid group of natural products and is a specific DNA topoisomerase I (Topo I) inhibitor (IC50=679 nM) with specificity. Camptothecin has antitumor activity and induces apoptosis.
T1910	Ansamitocin P 3'	Maytansinol butyrate,Ansamitocin P-3,Antibiotic C 15003P3'	Microtubule Associated
	Ansamitocin P 3' (Maytansinol butyrate) is an antibody-drug conjugate cytotoxin with antitumor activity.		Microtubule Associated
TP1180	Dolastatin 10	NSC 376128,DLS 10	Microtubule Associated
	Dolastatin 10 (DLS 10) is a powerful peptide with antimitotic properties, effectively inhibiting tubulin polymerization.		Microtubule Associated
T4677	MMAD	Monomethylauristatin D,Demethyldolastatin 10,Monomethyl Dolastatin 10	Microtubule Associated
	MMAD (Demethyldolastatin 10) is a potent tubulin inhibitor. MMAD is a toxin payload in antibody drug conjugates (ADCs).		Microtubule Associated